By Mark J. Pallen, Karen E. Nelson, Gail M. Preston
Details growth within the fast-changing international of bacterial genomics.
- Explains the clinical advances that experience resulted from the applying of bacterial genome sequencing to the research of the way bacterial pathogens have advanced and the way those micro organism reason sickness.
- Reviews the influence of genomics on our realizing of chosen teams of pathogens, together with Escherichia coli, mycobacteria, Neisseria, staphylococci, spirochetes, Campylobacter, plant pathogens, and Photorhabdus.
- Covers subject matters that minimize throughout taxonomic barriers, reminiscent of genomic signatures of intracellularity, the effect of shared genomic instruments and datasets, pathogenomics of bacterial biothreat brokers, the impression of phages at the evolution of bacterial pathogenicity, gram-positive protein secretion, mobilephone wall biosynthesis, and intracellular pathogens.
- Serves as a source for any bacteriology learn and as a key textual content for college students of bacterial genomics and the molecular foundation of bacterial infection.
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Extra info for Bacterial Pathogenomics
The strains were also selected so as to maximize the geographical distribution and host range, and to include both pathogenic and nonpathogenic varieties. A second collection, consisting of 78 diarrheagenic E. coli (DEC) strains representing the 15 major electrophoretic variants that were detected by MLEE (126), has also been assembled. edu/whittam). Phylogenetic analysis of the ECOR collection, which is based on neighbor-joining analysis of MLEE distance data for 38 enzyme loci (49; Fig. 1), separates the strains into ﬁve major groups: A, B1, B2, D, and E (sometimes considered to be unclassiﬁed).
It is unclear whether these are diarrheagenic, although there have been reports of the presence of a type III secretion system (8, 62). Enteroinvasive E. coli (EIEC) have perhaps the most distinctive lifestyle of all the E. coli pathotypes. Unlike the other pathotypes, EIEC demonstrate a true intracellular lifestyle and are capable of surviving and replicating within the cytoplasm and vacuoles of host colonic epithelial cells. EIEC share many characteristics with members of the Shigella genus, which are the cause of bacillary dysentery or shigellosis.
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