By Lesley-Ann Giddings, David J. Newman
This SpringerBrief sheds new gentle on bioactive fabrics from marine extremophiles. It bargains with all facets of the chemical substances produced by way of organisms residing lower than severe stipulations which may have power as medicines or bring about novel medicinal drugs for human use.
Read or Download Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology / Extremophilic Bacteria) PDF
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Additional resources for Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology / Extremophilic Bacteria)
Faecium, Haemophilus influenza, and E. coli. 5 to 12 μg/ml, respectively. 0 μg/ml and 2–10 μg/ml, respectively. In addition, lipoxazolidinones B and C (131–132) exhibited antimicrobial against strains of Haemophilus influenza with ranging MIC values of 12–16 μg/ml and 5–16 μg/ml, respectively. These compounds (130–132) are examples of unprecedented pharmacophores produced by a new genus of marine actinomycetes. Scientists at Nereus Pharmaceuticals, Inc. also reported the production of the ﬁrst series of chlorinated bisindole pyrroles, lynamicins A–E (133–137) (Fig.
In addition, the mixture of compounds exhibited slight cytotoxic activity against human lung adenocarcinoma A549 cells and baby hamster kidney cells with IC50 values of 42 and 25 μM, respectively. Additional puriﬁcation of these isomers will be necessary to determine the active component(s). , demonstrating the variety of secondary metabolites produced by unexplored phylogenetically distant taxa (Nett et al. 2006). In 2012, Kim and coworkers reported the production of two new 36-membered polyene polyol macrocyclic lactone antifungal agents, bahamaolides A and B (150– 151) (Fig.
2012b; Satoh et al. 2011). A summary of the total synthetic methods used can be found in a 2011 review by Ma et al. (2011b). In addition, having access to the salinosporamide A 154 biosynthetic genes from sequenced Salinispora genomes will help produce variations of salinosporamide A 154 with novel or enhanced bioactivity (Jensen et al. 2014). Chemoprevention is another area in which natural products have served as useful tools to understand the molecular basis of cancer progression or the development of 2 Culturable Marine Microbes 35 drugs to inhibit the development of cancer.