Download Bioprinting: Principles and Applications by Chee Kai Chua PDF

By Chee Kai Chua

At labs around the globe, researchers were experimenting with bioprinting, first simply to see no matter if it was once attainable to push cells via a printhead with no killing them (in so much instances it is), after which attempting to make cartilage, bone, pores and skin, blood vessels, small bits of liver and different tissues. There are alternative ways to aim to "engineer" tissue — one consists of making a scaffold out of plastics or different fabrics and including cells to it. In conception, no less than, a bioprinter has merits in manipulating regulate of the situation of cells and different parts to imitate normal structures.

yet simply because the claims made for 3D printing expertise occasionally exceed the truth, the sector of bioprinting has visible its percentage of hype. the truth is that, even if bioprinting researchers have made nice strides, there are lots of bold hindrances to beat. not anyone who has any credibility claims they could print organs, or believes of their center of hearts that that may occur within the subsequent twenty years, yet for operations like hip substitute, enhance in Bio-printing has made customization of convinced physique elements attainable.

This ebook will begin from the idea that of Tissue Engineering, overlaying quite a few techniques in Scaffolds for tissue engineering, Bioprinting recommendations and fabrics for bioprinting, mobilephone processing, 3D cellphone tradition strategies, Computational layout and simulation, multi-disciplinary ways in bioprinting and eventually conceal the functions of bioprinting.

Readership: Senior undergraduates, researcher scholars in tissue engineering, common public undefined.

Show description

By Chee Kai Chua

At labs around the globe, researchers were experimenting with bioprinting, first simply to see no matter if it was once attainable to push cells via a printhead with no killing them (in so much instances it is), after which attempting to make cartilage, bone, pores and skin, blood vessels, small bits of liver and different tissues. There are alternative ways to aim to "engineer" tissue — one consists of making a scaffold out of plastics or different fabrics and including cells to it. In conception, no less than, a bioprinter has merits in manipulating regulate of the situation of cells and different parts to imitate normal structures.

yet simply because the claims made for 3D printing expertise occasionally exceed the truth, the sector of bioprinting has visible its percentage of hype. the truth is that, even if bioprinting researchers have made nice strides, there are lots of bold hindrances to beat. not anyone who has any credibility claims they could print organs, or believes of their center of hearts that that may occur within the subsequent twenty years, yet for operations like hip substitute, enhance in Bio-printing has made customization of convinced physique elements attainable.

This ebook will begin from the idea that of Tissue Engineering, overlaying quite a few techniques in Scaffolds for tissue engineering, Bioprinting recommendations and fabrics for bioprinting, mobilephone processing, 3D cellphone tradition strategies, Computational layout and simulation, multi-disciplinary ways in bioprinting and eventually conceal the functions of bioprinting.

Readership: Senior undergraduates, researcher scholars in tissue engineering, common public undefined.

Show description

Read Online or Download Bioprinting: Principles and Applications PDF

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Bioprinting: Principles and Applications

At labs all over the world, researchers were experimenting with bioprinting, first simply to see no matter if it used to be attainable to push cells via a printhead with no killing them (in so much instances it is), after which attempting to make cartilage, bone, pores and skin, blood vessels, small bits of liver and different tissues. There are alternative routes to aim to "engineer" tissue — one comprises making a scaffold out of plastics or different fabrics and including cells to it.

Extra resources for Bioprinting: Principles and Applications

Example text

However, certain limitations should be addressed. FDM requires input material to be of a specific size. Moreover, any changes to material properties require recalibration of the roller feeding parameters. The resolution of the FDM process is 250 µm, which is lower than other AM methods to be introduced in the following sections. Available materials for FDM are quite limited. Natural polymers cannot be used since materials have to be in the filament form and melted during extrusion. The high system operating temperature impedes the incorporation of biomolecules into the scaffold.

2 Two-photon polymerisation Two-photon excitation provides energy to activate physical or chemical processes with high resolution in three-dimensional spaces, which facilitates the development of three-dimensional lithographic microfabrication [103, 104]. The two-photon absorption probability depends on intensity and thus, the absorption is constrained at the focus Scaffolds for Tissue Engineering 39 to a volume of order λ3 under tight-focusing conditions (λ is the laser wavelength) [105]. When tightly focusing a laser beam into the volume of a photosensitive resin, near infrared femtosecond laser pulses are nonlinearly absorbed by the material within the focal volume [106].

Another primary consideration in scaffold design is the inclusion of bioactive molecules including DNA, proteins and extracellular matrix (ECM)-like peptides. It should be noted that if bioactive molecules are included, the fabrication techniques that activate with those relevant molecules cannot be used since this will affect cell adhesion, signalling and drug and gene delivery. Cell migration, proliferation and differentiation can be significantly promoted through local drug and gene delivery, which improves the quality of tissue regeneration [15].

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