Download Biothiols, Part A: Monothiols and Dithiols, Protein Thiols, by John N. Abelson, Melvin I. Simon, Helmut Sies PDF

By John N. Abelson, Melvin I. Simon, Helmut Sies

The seriously acclaimed laboratory average for 40 years, Methods in Enzymology is without doubt one of the so much hugely revered guides within the box of biochemistry. given that 1955, each one quantity has been eagerlyawaited, often consulted, and praised by way of researchers and reviewers alike. greater than 250 volumes were released (all of them nonetheless in print) and lots more and plenty of the fabric is proper even today--truly an important book for researchers in all fields of existence sciences. Key positive aspects * Prevention of oxidative pressure * Redox rules of metabolism * Toxicology * Carcinogenesis

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By John N. Abelson, Melvin I. Simon, Helmut Sies

The seriously acclaimed laboratory average for 40 years, Methods in Enzymology is without doubt one of the so much hugely revered guides within the box of biochemistry. given that 1955, each one quantity has been eagerlyawaited, often consulted, and praised by way of researchers and reviewers alike. greater than 250 volumes were released (all of them nonetheless in print) and lots more and plenty of the fabric is proper even today--truly an important book for researchers in all fields of existence sciences. Key positive aspects * Prevention of oxidative pressure * Redox rules of metabolism * Toxicology * Carcinogenesis

Show description

Read or Download Biothiols, Part A: Monothiols and Dithiols, Protein Thiols, and Thiyl Radicals PDF

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Extra info for Biothiols, Part A: Monothiols and Dithiols, Protein Thiols, and Thiyl Radicals

Sample text

Biochem. 153, 57 (1986). 34 R. Zhang and G. H. Synter, Biochemistry 27, 3785 (1988). 3s S. C. Tyagi and S. R. Simon, Biochemistry 31, 10584 (1992). 36 K. Konishi and M. Fujioka, Arch. Biochem. Biophys. 289, 90 (1992). 16 OVERVIEW "12l TABLE I EQUILIBRIUM CONSTANTS (Kmix) FOR FORMATIONOF GLUTATH1ONE MIXED DISULFIDES EO! a Test system /(mix (volts) Ref. 090 31 a E o, values are calculated using Eq. (12) and a 1 M standard state for GSH. The E °' values reported may differ from previously tabulated values 1 because more accurate values for the equilibrium constant for glutathione reductase and the oxidation potential of dithiothreitol have been used.

Res. Toxicol. 3, 495 (1990). 6 M, 15 and metabolic changes in glutathione status are correlated with changes in cholesterol levels consistent with regulation of this biological process by reversible thiol/disulfide exchange. 2a A number of other proteins including enzymes and transcription factors have been suggested to undergo a similar type of regulation; however, the thiol/disulfide redox potentials of these proteins are not yet known. The formation of mixed disulfides between the intracellular glutathione redox buffer and specific proteins (S-thiolation) has been observed under oxidative stress imposed by the oxidation of the glutatione pool by exogenous oxidants such as diamide and hydrogen peroxideY Because equilibrium constants for mixed disulfide formation, Kmix, are usually near one, 1 significant accumulation of mixed disulfides at equilibrium should be low (compared to PSH) under normal physiological conditions where the ratio [GSH]/[GSSG] is greater than 100.

4sA. Shafferman,Isr. J. Chem. 10, 725 (1972). 46M. Z. Baker, R. Badiello,M. Tamba, M. Quintiliani,and G. Gorin, Int. J. Radiat. Biol. 41, 595 (1982).

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