Download Blood-Spinal Cord and Brain Barriers in Health and Disease by Hari Shanker Sharma PDF

By Hari Shanker Sharma

  • '''Blood-Spinal wire and mind limitations in well-being and affliction' is a modern and extremely informative quantity that are meant to be a prepared resource of reference for all researchers and clinicians occupied with the CNS in overall healthiness and disease.'' --Cerebrospinal Fluid learn (June 2005)

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By Hari Shanker Sharma

  • '''Blood-Spinal wire and mind limitations in well-being and affliction' is a modern and extremely informative quantity that are meant to be a prepared resource of reference for all researchers and clinicians occupied with the CNS in overall healthiness and disease.'' --Cerebrospinal Fluid learn (June 2005)

Show description

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Additional resources for Blood-Spinal Cord and Brain Barriers in Health and Disease

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8, 557–565. , and Menger, M. D. (2000). Intravital fluorescence videomicroscopy to study tumor angiogenesis and microcirculation. Neoplasia (New York) 2, 53–61. von Andrian, U. , and M’Rini, C. (1998). In situ analysis of lymphocyte migration to lymph nodes. Cell Adh. Comm. 6, 85–96. , and Meyermann, R. (1990). Passage of lymphocytes across the blood-brain barrier in health and disease. In “Pathophysiology of the Blood–Brain Barrier” (B. B. Johansson, C. Owman, and H. ), pp. 439–445. Elsevier, New York.

Magnification × 400. Fig. 8 Molecular mechanisms involved in T-cell recruitment across the blood–spinal cord and brain barrier in health and disease. Summary of the molecular events involved in T-cell recruitment across the healthy BBB during the initiation of EAE and by inflammatory cells across the inflamed BBB later during ongoing EAE as proposed from our results. Continued 3. M ECHANISMS I NVOLVED IN T LYMPHOCYTE R ECRUITMENT 29 Fig. , 1996; von Andrian and M’Rini 1998). VIII. Summary Taken together, we now have direct evidence that microvasculature constitutively expressed VCAM-1 in the spinal cord white matter mediates the G-protein-independent capture of circulating encephalitogenic T-cell blasts via the α4-integrin in vivo.

In contrast, within spinal cords derived from mice pretreated with either anti-VCAM-1 antibody or infused with T lymphoblasts pretreated with the anti-α4-integrin antibody, only a few fluorescently labeled T lymphoblasts could be detected exclusively within the lumen of spinal cord microvessels (Fig. 7). These observations demonstrate that G-protein-dependent α4-integrinmediated firm adhesion of T lymphoblasts to VCAM-1 on the endothelial surface is essential for their successful emigration into the spinal cord parenchyme.

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