By R-K Li and R.D. Weisel (Eds.)
Cardiac Regeneration and service, quantity reviews using biomaterials, on my own or mixed with telephone remedy, in delivering tissue-engineered constructs to fix the injured center and stop or opposite middle failure.
Part one explores the range of biomaterials to be had for cardiac fix, together with nanomaterials and hydrogels. additional chapters discover using biomaterials to augment stem mobilephone treatment for restoring ventricular functionality and producing stem cell-modified intravascular stents. half makes a speciality of tissue engineering for cardiac fix, together with chapters on decellularized biologic scaffolds, man made scaffolds, cellphone sheet engineering, maturation of useful cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro purposes, and scientific issues for cardiac tissue engineering. ultimately, half 3 explores vascular home improvement, together with chapters highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.
Cardiac Regeneration and service, quantity Two is complemented by way of an preliminary quantity masking pathology and treatments. jointly, the 2 volumes of Cardiac Regeneration and service provide a accomplished source for clinicians, scientists, or academicians occupied with cardiac regeneration, together with these attracted to mobilephone remedy, tissue engineering, or biomaterials.
- Surveys the range of biomaterials on hand for cardiac fix, together with nanomaterials and hydrogels.
- Focuses on tissue engineering for cardiac fix together with scientific issues for cardiac tissue engineering
- Explores vascular home improvement, highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels
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Extra info for Cardiac Regeneration and Repair. Biomaterials and Tissue Engineering
2011) modified PEG-vinyl sulfone hydrogels with MMP-cleavable peptides and integrin-binding ligands to produce a cell adhesive and degradable hydrogel. Using this biomimetic synthetic hydrogel, they delivered hESCs and thymosin β4, an angiogenic and pro-survival factor, 1 hour after total occlusion in a rat MI model. They noted that over weeks, as the hydrogel was degraded, cells in contact Hydrogels for cardiac repair 33 with the gel increased. By 6 weeks, the hydrogel was undetectable, but cells delivered with the hydrogel and thymosin β4 had significantly smaller infarct size and end diastolic volume than PBS-injected controls.
This study used neonatal rat skeletal myoblasts with a fibrin injection and showed that compared with conventional liquid delivery, fibrin improved myoblast survival by more than two-fold. , 2004a), but this was not statistically different 32 Cardiac regeneration and repair from injection of fibrin alone. , 2010). , 2010). As mentioned previously, alginate lacks the intrinsic motifs for cell adhesion, so to prevent anoikis of transplanted cells, modifications to alginate must be made to provide cell–matrix interactions.
The timing of this release was chosen such that VEGF induced endothelial cell migration and angiogenesis, followed by induction by PDGF of smooth muscle cell recruitment and growth. This is reflected histologically as the dual growth factor delivery had similar capillary density compared with VEGF alone but was able to induce higher arteriogenesis compared with either growth factor alone. Perhaps even more exciting, would be the sequential delivery of VEGF, PDGF and transforming growth factor-β1 (TGF-β1), all of which are important in the formation of functional vasculature (Freeman and Cohen, 2009).