By Roland Kaunas, Assaf Zemel
Explores a number Multiscale Biomechanics/Mechanobiology Concepts
Cell and Matrix Mechanics presents state-of-the-art learn on the molecular, mobile, and tissue degrees within the box of mobile mechanics. This e-book consists of key specialists within the box, and covers an important components of mobilephone and tissue mechanics, with an emphasis at the roles of mechanical forces in cell–matrix interactions. supplying fabric in each one bankruptcy that builds at the past chapters, it successfully integrates size scales and comprises, for every size scale, key experimental observations and corresponding quantitative theoretical versions.
Summarizes the 3 Hierarchical degrees of mobile Mechanics
The e-book includes 14 chapters and is equipped into 3 sections. the 1st part makes a speciality of the molecular point, the second one part info mechanics on the mobile point, and the 3rd part explores mobile mechanics on the tissue point. The authors provide an intensive description of the jobs of mechanical forces in phone and tissue biology, and comprise particular examples. They contain descriptions of linked theoretical versions, and supply the information and modeling framework wanted for a multi-scale research. furthermore, they spotlight the pioneering stories in cell–matrix mechanics by way of Albert okay. Harris.
The themes coated include:
- The passive and lively mechanical houses of cytoskeletal polymers and linked motor proteins besides the habit of polymer networks
- The mechanical homes of the phone membrane, with an emphasis on membrane protein activation attributable to membrane forces
- The hierarchical association of collagen fibrils, revealing soft stability exists among particular and nonspecific interactions to lead to a constitution with semicrystalline order in addition to free associations
- The roles of matrix mechanical houses on cellphone adhesion and serve as in addition to assorted mechanical mechanisms of cell–cell interactions
- The results of mechanical loading on telephone cytoskeletal home improvement, summarizing quite a few modeling methods that designate attainable mechanisms regulating the alignment of actin tension fibers in accordance with stretching
- The mechanical checking out of cell-populated collagen matrices, in addition to idea referring to the passive and energetic mechanical houses of the engineered tissues
- Cell migration habit in three-D matrices and in collective cellphone motility
- The position of mechanics in cartilage development
- The roles of either mobile and exterior forces on tissue morphogenesis
- The roles of mechanical forces on tumor progress and melanoma metastasis
Cell and Matrix Mechanics succinctly and systematically explains the jobs of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, in addition to graduate scholars in biomedical engineering and mechanical engineering with regards to mechanobiology, can make the most of this paintings.
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Extra resources for Cell and matrix mechanics
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K′-values can be directly compared with theoretical predictions based on semiflexible polymer models (Gardel et al. 2004). K′ is usually obtained by a differential prestress protocol, where small amplitude oscillations are superimposed on a steady-state shear flow. An alternative protocol that can be more suitable for materials exhibiting creep is a strain rate ramp protocol, where K′ is extracted by differentiating the stress/strain curve measured at different strain rates (Semmrich et al. 2007; Broedersz et al.