By Arnaud Chauvière, Luigi Preziosi, Claude Verdier
Ubiquitous and basic in mobile mechanics, multiscale difficulties can come up within the development of tumors, embryogenesis, tissue engineering, and extra. Cell Mechanics: From unmarried Scale-Based versions to Multiscale Modeling brings jointly new perception and study on mechanical, mathematical, actual, and organic techniques for simulating the habit of cells, in particular tumor cells.
In the 1st a part of the textual content, the publication discusses the robust software of microrheology for investigating phone mechanical houses, multiphysics and multiscale ways for learning intracellular mechanisms in phone motility, and the position of subcellular results concerning sure genes for inducing mobile motility in melanoma. concentrating on versions according to actual, mathematical, and computational methods, the second one part develops instruments for describing the complicated interaction of phone adhesion molecules and the dynamic evolution of the mobile cytoskeleton. The 3rd half explores cellphone interactions with the surroundings, rather the position of exterior mechanical forces and their results on phone habit. the ultimate half offers cutting edge versions of multicellular structures for developmental biology, melanoma, and embryogenesis.
This ebook collects novel ways to observe to cells and tissues via a multiscale strategy. It provides a number of present instruments whereas stimulating the invention of latest techniques which can result in more advantageous and actual predictions of pathologies.
Read or Download Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling (Chapman & Hall CRC Mathematical & Computational Biology) PDF
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Additional info for Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling (Chapman & Hall CRC Mathematical & Computational Biology)
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Desprat, D. Icard, S. Fereol, A. Asnacios, J. Browaeys, S. Henon, and F. Gallet (2006). Power laws in microrheology experiments on living cells: comparative analysis and modeling. Phys. Rev. E 74:021911. 003 < t < 30 s, which exactly matches the experimental range of our measurements. This reinforces the validity of our approach. From the same analysis performed on our data on alveolar epithelial cells A549 we infer that the highest response time is m ≈ 300 s for this type of cell. Other experiments  yield a typical time m ≈ 3200 s.
Application of the micropipette technique to the measurement of culture porcine aortic endothelial cell viscoelastic properties. J. Biomech. Eng. 112:263–268.  P. Sollich (1998). Rheological constitutive equation for a model of soft glassy materials. Phys. Rev. E 58:738–759.  O. Thoumine and A. Ott (1997). Time scale dependent viscoelastic and contractile regimes in ﬁbroblasts probed by microplate manipulation. J. Cell Sci. 110:2109–2116.  X. Trepat, M. Grabulosa, L. Buscemi, F. Rico, R.