Chapter IX Aminopyridines (pages 1–177): Andrew S. Tomcufcik and Lee N. Starker
Chapter X Pyridinecarboxylic Acids (pages 179–346): Eugene P. Oliveto
Chapter XI Pyridine Side?Chain Carboxylic Acids (pages 347–507): John C. Godfrey
Chapter XII Pyridinols and Pyridones (pages 509–890): Herbert Meislich
Read or Download Chemistry of Heterocyclic Compounds: Pyridine and its Derivatives, Part Three, Volume 14 PDF
Best chemistry books
Hydrocarbons and their changes play significant roles in chemistry as uncooked fabrics and resources of power. Diminishing petroleum offers, regulatory difficulties, and environmental issues always problem chemists to reconsider and remodel the commercial purposes of hydrocarbons. Written by way of Nobel Prize-winner George Olah and hydrocarbon specialist Árpád Molnár, the thoroughly revised and improved moment version of Hydrocarbon Chemistry presents an extraordinary modern evaluation of the sector, offering simple strategies, present learn, and destiny functions.
Heterogeneous catalysis performs a big function within the natural synthesis of strong point and high-quality chemical substances. besides the fact that, because the interplay among floor websites and sensible teams is advanced, extra investigations are precious into the consequences of catalysts at the response mechanisms. The 3rd foreign Symposium on Heterogeneous Catalysis and advantageous chemical substances supplied a chance for discussions at the uncomplicated and useful elements of this topic among researchers, brands and clients of sturdy catalysts for synthesis of excellent chemical compounds.
Content material: Antibodies : analytical instruments to review environmentally vital compounds / Helen Van Vunakis -- Immunoassay evaluate directions. Immunoassays in meat inspection : makes use of and standards / David B. Berkowitz -- Monoclonal antibody expertise software / Stephen Krogsrud and Kenneth T. Lang -- improvement of drug residue immunoassays : technical issues / John J.
- Copolymers, Polyblends, and Composites
- Chemistry of Heterocyclic Compounds: s-Triazines and Derivatives, Volume 13
- Chemical Hazards in the Workplace. Measurement and Control
- Quantum Modeling of Complex Molecular Systems
Extra info for Chemistry of Heterocyclic Compounds: Pyridine and its Derivatives, Part Three, Volume 14
These reactions are more fully discussed on p. 31. I n contrast to alkylation, which requires the sodium salt of the amine, arylations can be performed on the base itself. Thus Chichibabin (304) reported that 2-aminopyridine and bromobenzene J ielded 2-anilinopyridine under the conditions of the Ullman reaction. However, later workers (305) were not able to duplicate his results, but were successful when they substituted iodobenzene for the bromobenzene. 2-Anilinopyridine has also been prepared from 2,2-dichloro-l,2-dihydro-l-phenylpyridine (prepared from 2-pyridone and phosgene) and liquid ammonia (306), and from pyridine and the sodium salt of aniline (7).
12. h'uclear Substitution Reactions (a) Halogenation. In contrast with pyridine itself, aminopyridines halogenate very readil) , and the halogen derivatives thus obtained are useful intermediates for synthesis. Their physical properties are summarized in Tables IX-13 to IX-19 (pp. ). 67). Continued chlorination under these conditions gives 2-amino-3,5-dichloropyridinein 75y0 yield. T h e structure of the monochloro derivative was proved by its preparation from 2,5-diaminopyridine by the Sandmeyer reaction (341).
T h e deamination reaction has been effected with ethanol (352) on diazotized 4-amino-3-pyridinesulfonic acid, and with hypophosphorous acid on diazotized ethyl 5-amino-2-methylnicotinate (6) in 627, yield, Other replacements, generally analogous to procedures in benzene chemistry, have been reported. Potassium ethyl xanthate (357) gives the disulfide (IX-23), mercaptoacetic acid (358) gives pyridylmercaptoacetic acid (IX-24), and copper thiocyanate gives S-thiocyanopyridine (IX-25). 59-362). These reactions fail, however, when the aminopyridine is unsubstituted (276).