By Ahindra Nag
The most recent BREAKTHROUGHS IN COMPUTER-AIDED DRUG layout AND supply This definitive textual content presents in-depth info on computer-assisted innovations for locating, designing, and optimizing new, powerful, and secure medicinal drugs. Computer-Aided Drug layout and supply structures bargains goal and quantitative information at the use and supply of gear in people. allowing applied sciences akin to bioinformatics, pharmacokinetics, biosensors, robotics, and bioinstruments are completely mentioned during this leading edge paintings. assurance contains: Computer-aided drug layout (CADD) Drug supply platforms Bioinformatics of drug molecules and databases Lipase- and esterase-mediated medications and drug intermediates Pharmacokinetics and pharmacodynamics of gear Biomarkers, biosensors, and robotics in medication Biomedical instrumentation
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Additional info for Computer-Aided Drug Design and Delivery Systems
2. It should strongly adhere to the skin and should be resistant to routine disturbances such as bathing, clothing, abrasion, and exercise. 3. It should be easily removable. 4. It should have intimate contact with the skin at both the macroscopic and the microscopic levels. The pressure-sensitive adhesive should be positioned on the face of the delivery system or at the back of the device. A face adhesive– based transdermal system should possess some additional characteristics, including the following: 1.
The World Wide Web (WWW) is really astonishing and provides good access to biologic information. Depending on the type of data at hand, there are two basic ways to search: 1. Using descriptive words to search text databases 2. Using a nucleotide or protein sequence to search sequence databases The three database systems tools are Entrez, SRS, and DBGET. goc/Entrez). This Entrez system provides access to nucleotide and protein sequence databases, a molecular modeling of 3D structures database, a genomes and maps database, and a literature database.
The two important factors associated with the metabolism of the drug are first the ability of the drug to induce or inhibit enzyme synthesis that results in a fluctuating blood drug level with chronic dosing. The other factor is the fluctuating blood drug level owing to intestinal metabolism or a hepatic first-pass effect. 4â•… Elimination and Biologic Half-Life The rate of elimination of a drug is described quantitatively by its biologic half-life t½. 5â•… Safety Considerations The most widely used measure of the margin of safety of a drug is its therapeutic index TI: TI = TD50/ED50 where TD50 is the median toxic dose, and ED50 is the median effective dose.