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By J. M. Brass (auth.), A. Clarke, R. W. Compans, M. Cooper, H. Eisen, W. Goebel, H. Koprowski, F. Melchers, M. Oldstone, R. Rott, P. K. Vogt, H. Wagner, I. Wilson (eds.)

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By J. M. Brass (auth.), A. Clarke, R. W. Compans, M. Cooper, H. Eisen, W. Goebel, H. Koprowski, F. Melchers, M. Oldstone, R. Rott, P. K. Vogt, H. Wagner, I. Wilson (eds.)

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Brass MALTOPORI N OM PPS CM • malG • mal F -, mal E lamB mol A • • AmalE444 AmolB112 Fig. 12. The maltose transport system. The genetic organization of the malB region as well as the localization and the interaction of malB gene products is shown. The malB region consists of two divergent operons transcribed from promoters PL and PRo The malE gene codes for MBP, lamB codes for maltoporin (or A. receptor), and malF, G, K code for the cytoplasmic membrane components of the transport system. The molA gene, whose function is unknown, is expressed as part of the malK-lamB operon (GILSON 1983).

MalK might be the target for the inhibitory activity exerted by the phosphotransferase system, since mutants resistant to the transient inhibitory effect of glucose were found to map in MalK (SCHWARTZ and SAIER 1983, unpublished). 2 Transport of Substrate Across the Inner Membrane The common feature of all binding-protein-dependent transport systems, including the maltose transport system, is that the inner membrane components do not take up free substrate, but rather only substrate delivered by binding protein.

30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. NR NR NR NR NR NR MPO AS MAY et al. (in press) HIGGINS et al. (in press) HIGGINS (1984) HIGGINS and HARDIE (1983) MANSON et al. (1986) Lo and SANWAL (1975) SWEET et al. (1983) ARGAST and Boos (1979) MEDVECZKY and ROSENBERG (1970) PARDEE et al. (1966) ISIHARA and HOGG (1980) LANGRIDGE et al. (1970) GRIFFITH and LEACH (1973) ND, not determined. NR, not reported Lower S. typhimurium yield correlates with lower chemostactic response [4] b From sequence C Reported that indicated sugar BP act as chemoreceptors, but that amino acid BP do not [14] d Crystallization using 2-methyl-2,4-pentanediol (MPO), polyethylene glycol (PEG), or ammonium sulfate (AS) e See following list of references: 40000 E.

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