By Erem Bilensoy
Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine covers a variety of wisdom on cyclodextrins, from an outline of molecular and supramolecular points of cyclodextrin physicochemistry, to the newest results in cyclodextrin use and destiny probabilities within the employment of those structures. This booklet specializes in the derivatives and physicochemical and organic houses of cyclodextrins, and considers drug supply via topical, mucosal, and oral through cyclodextrin complexes.
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Extra info for Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine: Current and Future Industrial Applications
On the specificity of cyclodextrin complexes detected by electrospray mass spectroscopy. J. Am. Soc. , 13, 946–953. 7. , Hazai, E. (2007). Cyclodextrin complexes: chiral recognition and complexation behavior. Curr. Drug Discov. , 4, 282–294. 8. , Masson, M. (2003). The effects of organic salts on the cyclodextrin solubilization of drugs. Int. J. , 262, 101–107. 9. H. (2002). Study of the supramolecular inclusion of b-cyclodextrin with andrographolide. J. Inclusion Phenom. , 43, 259–264. 10. F.
The final product had to be washed by organic solvent to eliminate the excess of nonincluded guest. Of course, there are many disadvantages to this technique. To obtain an acceptable yield, it is usually necessary to use a cosolvent of the guest, such as an organic solvent, which unfortunately competes with the guest for inclusion in the CD; and in any case, the yield is very low and the method rather long. Also, and significantly, to be able to precipitate, the complex (and the parent CD) must have low solubility, so the method is restricted to b-CD.
Pharm. Biomed. , 49, 227–233. 27. B. (2007). Solid-state characterization and dissolution profiles of the inclusion complexes of omeprazole with native and chemically modified b-cyclodextrin. Eur. J. Pharm. , 67, 531–539. 28. M. (2009). The influence of the preparation methods on the inclusion of model drugs in a b-cyclodextrin cavity. Eur. J. Pharm. , 71, 377–386. 29. M. (2008). Inclusion complexes of tadalafil with natural and chemically modified b-cyclodextrins: I. Preparation and in-vitro evaluation.