Download Evidence-based neurology : management of neurological by Livia Candelise; et al PDF

By Livia Candelise; et al

''Evidence-based Neurological Management'' presents an evidence-based method of the administration of the entire significant neurological stipulations. This scientific textbook includes in-depth systematic experiences of the simplest proof within the box and contours major neurologists from the Cochrane Collaboration as its editors. This crucial textual content is usually on hand in an digital model, and is saved updated through its website.

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By Livia Candelise; et al

''Evidence-based Neurological Management'' presents an evidence-based method of the administration of the entire significant neurological stipulations. This scientific textbook includes in-depth systematic experiences of the simplest proof within the box and contours major neurologists from the Cochrane Collaboration as its editors. This crucial textual content is usually on hand in an digital model, and is saved updated through its website.

Show description

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1). The main disadvantage of relative measures (RRR) is that they do not account for the baseline risk. 1 Definition of commonly used measures of therapeutic efficacy Treatment Adverse event Present Absent Yes No (control) a c b d Control event rate Experimental event rate Relative risk Relative risk reduction Absolute risk difference Control odds Experimental odds Odds ratio Number needed to treat CER ϭ c/c ϩ d EER ϭ a/a ϩ b RR ϭ EER/CER RRR ϭ 1 Ϫ RR ARD ϭ CER Ϫ EER CO ϭ c/d EO ϭ a/b OR ϭ EO/CO or ad/bc NNT ϭ 1/ARD 18 Part 1: Introduction reducing the risk of seizure recurrence from 90% with medical therapy to 40% with temporal lobe surgery yields an RRR of 56% and an NNT of 2.

Imbalance in confounders may predetermine the results and is a serious threat to the validity of the results. The universal approach to balancing confounders among experimental and control groups is randomization. In this process, each patient has an equal chance of receiving experimental or control interventions. Ideally, randomization results in experimental and control patients that are Chapter 3: Outcome and adverse effect measures in neurology similar in every respect but the intervention under investigation.

Occurrence of seizures versus not) can yield ARDs and NNTs, they lend themselves to clinical interpretation and application of research results at the bedside. g. g. standard deviation or standard error). How are clinicians to interpret these reports? Typically, studies exploring the impact of treatments on continuous measures compare the means in treatment and control groups and assess whether the differences are statistically significant. However, the clinical importance of grouped or mean changes is difficult to interpret, regardless of their statistical significance.

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