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By D. Mathieu

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By D. Mathieu

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Others authors (Mathiew, 2007, Liew, 2011) have found in multivariate analysis that cerebellar tumor location was associated to poorer survival. Regarding tumor location, “scarce information with a trend” suggests that brainstem location, deep brain location and cerebellar location of a melanoma metastasis could be negative prognostic factors. 12 Latency period to brain metastases diagnose The time elapsed between the diagnosis of the cancer and the moment of the apparition of brain metastases has been propose as a prognostic factor, two studies have shown this association on multivariate analysis (Flanery, 2003; Rades, 2007) and 3 studied on univariate analysis (Yu, 2005; Kased, 2009; Liew, 2011).

Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases. Int J Radiat Oncol Biol Phys, Vol. 47, No. 4, pp. 1001-1006, ISSN 0360-3016 Gavrilovic, I. & Posner, J. (2005). Brain metastases: epidemiology and pathophysiology. J Neurooncol, Vol. 75, No. 1, pp. ; et al. (2011). Detection of brain micrometastases by highresolution stereotactic magnetic resonance imaging and its impact on the timing of and risk for distant recurrences. J Neurosurg, Vol. ; et al. (2003).

3, pp. 449-457, ISSN 0022-3085 Karnofsky, D. & Burchenal, J. (1949). The clinical evaluation of chemotherapeutic agents in cancer, In: Evaluation of Chemotherapeutic Agents, MacCleod (ed), p. ; et al. (2006). Whole-brain radiation in the management of brain metastases. J Clin Oncol, Vol. 24, No. 8, pp. ; et al. (2008). Gamma Knife radiosurgery for ten or more brain metastases. J Korean Neurosurg Soc, Vol. 44, No. 6, pp. ; et al. (2006). Gamma Knife surgery targeting the resection cavity of brain metastasis that has progressed after whole-brain radiotherapy.

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