By Howard J. Allen, Edward C. Kisailus
Roswell Park melanoma Institute, Buffalo, manhattan. entire, present precis of glycoconjugate biochemistry for researchers and complicated scholars. 29 individuals. DNLM: Glycoconjugates.
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Roswell Park melanoma Institute, Buffalo, ny. accomplished, present precis of glycoconjugate biochemistry for researchers and complicated scholars. 29 individuals. DNLM: Glycoconjugates.
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J. B. Lippincott, Philadelphia, pp. 115. 6. Rademacher, T. , Parekh, R. , and Dwek, R. A. (1988). Glycobiology. Annu. Rev. Biochem. 57:785838. 7. Spiro, R. J. (1970). Glycoproteins. Annu. Rev. Biochem. 39:599638. 8. , and Kornfeld, S. (1985). Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 54:631664. 9. Paulson, J. , and Colley, K. J. (1989). Glycosyl transferases. J. Biol. Chem. 264:1761517618. 10. Eylar, E. H. (1965). On the biological role of glycoproteins. J. Theor. Bio..
Furthermore, developments in these areas would certainly result in the availability of extensive information on the three-dimensional structures of glycoproteins, and this, in turn, should lead to new insights into the role of carbohydrates. To understand the factors that control the alteration in the glycosylation that occurs during different normal and abnormal physiological states, it would be necessary to study the regulation of expression of glycosidases and glycosyltransferases involved in the assembly of glycans.
Dolichol (Doc) is a polyisoprenol containing 1620 isoprene units, the first being saturated. Dolicholphosphorylmonosaccharides such as Glc-P-Dol and Man-P-Dol are formed from dolichol phosphate (Doc-P) as an acceptor and UDP-Glc and GDP-Man as sugar donors, respectively, in the presence of appropriate enzymes. The lipid-linked oligosaccharide, Glc3Man9GlcNAc2-P-P-Dol is assembled on Dol-P by step wise addition of monosaccharides, with the exception of the first sugar, which is inserted as GlcNAc-1-P from the respective sugar nucleotides and dolicholphosphoryl sugars.