By Alexander S. Pasciak PhD., Yong Bradley MD., J. Mark McKinney MD.
Radioembolization is a normal therapy for non-resectable fundamental and secondary liver melanoma. This instruction manual addresses the radiation biology, physics, nuclear medication, and imaging for radioembolization utilizing Yttrium-90 (90Y) microspheres, as well as discussing elements regarding interventional radiology. The contents consider and off-label remedy symptoms, dose-response relationships, treatment-planning, remedy optimization, radiation defense, imaging follow-up and plenty of different features of this remedy important for either beginner and complex clients alike.
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Extra info for Handbook of Radioembolization: Physics, Biology, Nuclear Medicine, and Imaging
Using a scout dose of particles identical to the treatment microspheres, such as with 166 Ho-microspheres, may provide a more accurate prediction of the intrahepatic therapeutic microsphere distribution. Further investigation is required to confirm this hypothesis, because differences in catheter positioning between the scout procedure and the therapy procedure may also play an important role. , 2015a). 6 PRETREATMENT ACTIVITY CALCULATIONS Different methods for pretreatment activity calculations (pretreatment dosimetry) have been proposed.
Et al. (2010). Radioembolization with yttrium-90 glass microspheres in hepatocellular carcinoma: European experience on safety and long-term survival. Hepatology 52:1741–1749. , Buckner, G. (2015). Selective internal radiation therapy: Quantifying distal penetration and distribution of resin and glass microspheres in a surrogate arterial model. J Vasc Interv Radiol 26:897–904. Available at http://www. gov/pubmed/25891507. S. et al. (2013). Post-radioembolization yttrium-90 PET/CT - part 2: Dose-response and tumor predictive dosimetry for resin microspheres.
Nat Rev Clin Oncol 11:525–535. doi. 122 [Accessed August 6, 2014]. R. (2004). External beam radiation therapy for hepatocellular carcinoma: Potential of intensity-modulated and image-guided radiation therapy. Gastroenterology 127:206–217. M. et al. (2009). Radiation lobectomy: Preliminary findings of hepatic volumetric response to lobar yttrium-90 radioembolization. Ann Surg Oncol 16:1587–1596. gov/pubmed/19357924 [Accessed August 4, 2014]. Garin, E. (2015). Radioembolization with 90Y-loaded microspheres: High clinical impact of treatment simulation with MAA-based dosimetry.