Download Hydrolases in Organic Synthesis: Regio- and Stereoselective by Prof. Dr. Uwe T. Bornscheuer, Prof. Dr. Romas J. PDF

By Prof. Dr. Uwe T. Bornscheuer, Prof. Dr. Romas J. Kazlauskas(auth.)

From reports to the 1st edtion:

"Bornscheuer and Kazlauskas have set out, and succeeded, in generating a definitive handbook on hydrolytic enzymes (especially lipases, esterases, and proteases) for natural chemists. this can be without problems the easiest booklet of its kind and will be unreservedly suggested to natural chemists who've an curiosity in utilizing hydrolytic enzymes in synthesis." (Nicholas J. Turner, collage of Edinburgh)

"The e-book is an critical resource of knowledge at the use of hydrolases in natural synthesis. the subject material is especially good set out, and the chapters are truly written and offered from a severe point of view. Bornscheuer and Kazlauskas have succeeded admirably in describing the features and barriers of using hydrolytic enzymes and in severely comparing them. No library can be with out the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin)

the second one variation of this super winning and well-proven ebook provides contemporary advancements within the use of hydrolases for natural synthesis, reflecting specifically the big development made in enzyme discovery and optimization with a brand new bankruptcy on "Protein assets and Optimization of Biocatalyst Performance".
The well known authors survey the stereoselective reactions of hydrolases, specially lipases, esterases and proteases, giving researchers an summary of what has labored long ago as a way to pass judgement on the way to remedy their very own artificial difficulties. In overall, the publication comprises over 1000 chemical constructions, rounded off by way of a few 1,800 priceless references.

Content:
Chapter 1 creation (pages 1–3):
Chapter 2 Designing Enantioselective Reactions (pages 5–24):
Chapter three picking out response Media: Water and natural Solvents (pages 25–42):
Chapter four Protein resources and Optimization of Biocatalyst functionality (pages 43–59):
Chapter five Lipases and Esterases: Sections 5.1 ? 5.2 (pages 61–140):
Chapter five Lipases and Esterases: Sections 5.3 ? 5.4 (pages 141–183):
Chapter 6 Proteases and Amidases (pages 185–210):
Chapter 7 Phospholipases (pages 211–214):
Chapter eight Epoxide Hydrolases (pages 215–226):
Chapter nine Hydrolysis of Nitriles (pages 227–240):
Chapter 10 different Hydrolases (pages 241–248):

Show description

By Prof. Dr. Uwe T. Bornscheuer, Prof. Dr. Romas J. Kazlauskas(auth.)

From reports to the 1st edtion:

"Bornscheuer and Kazlauskas have set out, and succeeded, in generating a definitive handbook on hydrolytic enzymes (especially lipases, esterases, and proteases) for natural chemists. this can be without problems the easiest booklet of its kind and will be unreservedly suggested to natural chemists who've an curiosity in utilizing hydrolytic enzymes in synthesis." (Nicholas J. Turner, collage of Edinburgh)

"The e-book is an critical resource of knowledge at the use of hydrolases in natural synthesis. the subject material is especially good set out, and the chapters are truly written and offered from a severe point of view. Bornscheuer and Kazlauskas have succeeded admirably in describing the features and barriers of using hydrolytic enzymes and in severely comparing them. No library can be with out the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin)

the second one variation of this super winning and well-proven ebook provides contemporary advancements within the use of hydrolases for natural synthesis, reflecting specifically the big development made in enzyme discovery and optimization with a brand new bankruptcy on "Protein assets and Optimization of Biocatalyst Performance".
The well known authors survey the stereoselective reactions of hydrolases, specially lipases, esterases and proteases, giving researchers an summary of what has labored long ago as a way to pass judgement on the way to remedy their very own artificial difficulties. In overall, the publication comprises over 1000 chemical constructions, rounded off by way of a few 1,800 priceless references.

Content:
Chapter 1 creation (pages 1–3):
Chapter 2 Designing Enantioselective Reactions (pages 5–24):
Chapter three picking out response Media: Water and natural Solvents (pages 25–42):
Chapter four Protein resources and Optimization of Biocatalyst functionality (pages 43–59):
Chapter five Lipases and Esterases: Sections 5.1 ? 5.2 (pages 61–140):
Chapter five Lipases and Esterases: Sections 5.3 ? 5.4 (pages 141–183):
Chapter 6 Proteases and Amidases (pages 185–210):
Chapter 7 Phospholipases (pages 211–214):
Chapter eight Epoxide Hydrolases (pages 215–226):
Chapter nine Hydrolysis of Nitriles (pages 227–240):
Chapter 10 different Hydrolases (pages 241–248):

Show description

Read or Download Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations, Second Edition PDF

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Extra info for Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations, Second Edition

Sample text

5 and triolein synthesis was fastest at low values of aw (Dudal and Lortie, 1995). It may also be useful to change aw as the reaction proceeds. , 1994). Water activity also influenced the enantioselectivity of lipase-catalyzed reaction, but not in a consistent manner. The effect varied with solvent and also whether the chiral moiety was in the acyl or alcohol part of the substrate. For the resolution of 2-methyl alkanoic acids with CRL (Eq. , 1993). , 1995; Hansen et al. , 1993). 75. However, for dichloromethane and t-amyl alcohol the enantioselectivity was independent of water activity and for vinyl acetate and 3-pentanone the enantioselectivity was higher at high water activity.

1992) Kamat et al. (1992; 1993) Chulalaksananukul et al. (1993) Castillo et al. (1994) Chaudhary et al. (1995) Ikushima et al. (1993) Bornscheuer et al. (1996); Capewell et al. (1996) Cernia et al. (1994a; b) Michor et al. (1996) Rantakylae and Aaltonen (1994) Jackson et al. 3 B: batch reactor; C: continuous reactor; S-C: semi-continuous reactor; IPI: integrated product isolation; PBA: phenyl boronic acid; b c IA: isopropenyl acetate; TA: triacetylglycerol. Ethane, ethylene, fluoroform, propane, sulfur hexafluoride also.

27. N N PF6 BMIM·PF6 N N NTf2 BMIM·NTf2 Common ionic liquids in biocatalysis – 1-butyl-3-methylimidazolium salts. The 1-alkyl-3-methylimidazolium ionic liquids are polar solvents. They are miscible with polar solvents like methylene chloride and immiscible with n-hexane and usually water. Reichardt's dye indicates that the polarity of common ionic liquids is similar to that of methanol, 2-chloroethanol, or N-methylformamide. , 1994; Park and Kazlauskas, 2001), the ionic liquids surprisingly do not, even though they have the same polarity.

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