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By D. Monleon

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By D. Monleon

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1993). Tamoxifen 40 mg/m2 was given BID for 4 days, then 10mg BID thereafter. Out of 19 patients that were eligible to continue the study, 1 achieved an MRI-documented partial response, while 2 had a minor CTdocumented response of short duration (4 and 20 months). Six patients remained stable for a median duration of 31 months, while 10 (53%) demonstrated progression. This study, as well as the other rare reports fail to prove the benefits of estrogen receptor inhibition in treatment of meningiomas.

Reference lists in articles were examined for further pertinent material. Articles were included when they contained quantitative data about the outcome and recurrence rate after surgical treatment of spinal meningiomas. 3 Selection and analysis of articles Information extracted from eligible studies included the following variables: study design, patient age, gender, instrumentation, histological features, functional outcome, recurrence rate, and adjuvant therapies. , 2005) involving 10 patients with lumbar and lumbosacral spinal meningiomas.

5 Hydroxyurea Hydroxyurea, an oral ribonucleotide reductase inhibitor, arrests meningioma cell growth in the S phase of the cell cycle and induces apoptosis. Preliminary reports on use of hydroxyurea appeared promising, but the phase II studies that followed these initial results failed to prove significant efficacy. , 2010). , 2009) included patients with unresectable, measurable, residual or recurrent, histologically proven benign meningiomas. The study was closed after 29 patients were accrued, due to the slow subject recruitment rate.

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