By Barbara H. Iglewski
The experiences during this quantity care for questions of the mechanisms of pathogenesis and with organisms that experience only in the near past been generally studied at the molecular level.**The introductory part provides an summary of pathogenesis, emphasizing universal parts and genetic mechanisms of rules and a evaluation at the inhabitants genetics of bacterial pathogenesis. the second one part bargains with the rules of synthesis of floor parts and their function within the colonization of the host and/or of the host immune structures. The 3rd part covers the invasion and intracellular development of facultative and obligate intracellular parasites. The final part is dedicated to experiences of the function of bacterial poisonous items in pathogenesis.
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Extra info for Molecular Basis of Bacterial Pathogenesis
Genetic population structure, clonal phylogeny, and patho genicity in Salmonella paratyphi B. Infect. Immun. (in press). Selander, R. , Smith, Ν. , Rubin, F. , Kopecko, D. , Tall, B. D . , and Musser, J. M. (1990b). Evolutionary genetic relationships of clones of Salmonella serovars causing human typhoid and other enteric fevers. Infect. Immun. (submitted for publication). Smith, Ν. , and Selander, R. K. (1990). Sequence invariance of the antigen-coding central region of the phase 1 flagellar filament gene (fliC) among strains of Salmonella typhimurium.
This concept implies little or no exchange of chromosomal genes among individuals by homologous recombination. , 1987; see also Chapter 1). , 1983; Achtman and Pluschke, 1986). The clones of E. coli associated with meningitis in the neonate differ from other E. coli strains in that they possess the specific virulence traits that allow the organism to colonize the intestinal mucosa of the neonate, to invade and survive systemically, and to penetrate the blood-brain barrier. Kl E. , 1976). This observation is in contrast to the low carriage rates of the other encapsulated bacteria causing meningitis such as H.
4 9 , 6 8 - 7 4 . Sawyer, S. Α . , Dykhuizen, D. , DuBose, R. , Wolczyk, D. , and Hartl, D. L. (1987). Distribution and abundance of insertion sequences among natural isolates of Escherichia coli. Genetics 1 1 5 , 5 1 - 6 3 . Schill, W. , Phelps, S. , and Pyle, S. W. (1984). Multilocus electrophoretic assessment of the genetic structure and diversity of Yersinia ruckeri. Appl. Environ. Microbiol. 4 8 , 9 7 5 - 9 7 9 . Selander, R. , and Levin, B. R. (1980). Genetic diversity and structure in Escherichia coli populations.