Download Molecular Mechanisms of Bacterial Infection via the Gut by Le Shen (auth.), Chihiro Sasakawa (eds.) PDF

By Le Shen (auth.), Chihiro Sasakawa (eds.)

Our intestine is colonized via various micro organism all through our lifestyles, and the intestine epithelium is consistently uncovered to international microbes and nutritional antigens. hence, the intestine epithelium acts as a barrier opposed to microbial invaders and is provided with numerous innate protection platforms. Resident commensal and international invading micro organism have interaction in detail with the intestine epithelium and will impression host mobile and innate immune responses. From the point of view of many pathogenic micro organism, the intestine epithelium serves as an infectious foothold and port of access for disseminate into deeper tissues. In a few situations while the intestinal safety job and host immune process develop into compromised, even commensal and opportunistic pathogenic micro organism can move the barrier and begin neighborhood and systematic infectious illnesses. Conversely, a few hugely pathogenic micro organism, similar to these highlighted during this ebook, may be able to colonize or invade the intestinal epithelium regardless of the intestine barrier functionality is undamaged. for this reason, the connection among the protective job of the intestinal epithelium opposed to microbes and the pathogenesis of infective microbes turns into the foundation for retaining a fit existence.

The authors provide an summary of the present subject matters relating to significant gastric and enteric pathogens, whereas highlighting their hugely developed host (human)-adapted infectious approaches. basically, an in-depth learn of bacterial infectious suggestions, in addition to the host mobile and immune responses, awarded in every one bankruptcy of this publication will offer additional perception into the serious roles of the host innate and adaptive immune structures and their significance in deciding upon the severity or thoroughly fighting infectious illnesses. in addition, lower than the continual chance of rising and re-emerging infectious ailments, the subject of gut-bacteria molecular interactions will offer a variety of clues and concepts for the advance of latest healing thoughts.

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By Le Shen (auth.), Chihiro Sasakawa (eds.)

Our intestine is colonized via various micro organism all through our lifestyles, and the intestine epithelium is consistently uncovered to international microbes and nutritional antigens. hence, the intestine epithelium acts as a barrier opposed to microbial invaders and is provided with numerous innate protection platforms. Resident commensal and international invading micro organism have interaction in detail with the intestine epithelium and will impression host mobile and innate immune responses. From the point of view of many pathogenic micro organism, the intestine epithelium serves as an infectious foothold and port of access for disseminate into deeper tissues. In a few situations while the intestinal safety job and host immune process develop into compromised, even commensal and opportunistic pathogenic micro organism can move the barrier and begin neighborhood and systematic infectious illnesses. Conversely, a few hugely pathogenic micro organism, similar to these highlighted during this ebook, may be able to colonize or invade the intestinal epithelium regardless of the intestine barrier functionality is undamaged. for this reason, the connection among the protective job of the intestinal epithelium opposed to microbes and the pathogenesis of infective microbes turns into the foundation for retaining a fit existence.

The authors provide an summary of the present subject matters relating to significant gastric and enteric pathogens, whereas highlighting their hugely developed host (human)-adapted infectious approaches. basically, an in-depth learn of bacterial infectious suggestions, in addition to the host mobile and immune responses, awarded in every one bankruptcy of this publication will offer additional perception into the serious roles of the host innate and adaptive immune structures and their significance in deciding upon the severity or thoroughly fighting infectious illnesses. in addition, lower than the continual chance of rising and re-emerging infectious ailments, the subject of gut-bacteria molecular interactions will offer a variety of clues and concepts for the advance of latest healing thoughts.

Show description

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Additional info for Molecular Mechanisms of Bacterial Infection via the Gut

Example text

Along this surface, the intestinal epithelial cells are continuously exposed to commensal bacteria that reside in the intestinal lumen, as well as dietary and environmental antigens. Such interactions provide constant immunological stimulation. Indeed, a large number of immune cells, distribute throughout the gastrointestinal tract. Despite the harsh environment, under normal conditions the mucosal immune system in the gut is maintained to be hyporesponsive to environmental stimuli. However, the intestinal immune system is capable of rapidly mounting an immune response against pathogens.

1 Cell Surface Structures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Motility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

40 Historical Perspective on Animal Models of V. cholerae Pathogenicity . . . . . . . . . 41 V. cholerae Genes Important for Intestinal Colonization . . . . . . . . . . . . . . . . . 1 Cell Surface Structures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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