By Cristiana Tanase, Irina Ogrezeanu, Corin Badiu
The pituitary gland is a crucial one because it controls numerous of the opposite hormone glands, corresponding to the thyroid and adrenals. A pituitary adenoma is an irregular development or tumor during this gland, and they're the topic of very energetic medical and pathological research.
This e-book examines the newest advancements during this box and discusses an important molecules implicated in apoptosis, angiogenesis and sign transduction. an excellent realizing of those tactics is required to spot the simplest therapies.
- Facilitates the certainty of the procedures concerned and the way they're translated into therapy
- Illustrations are used to provide an explanation for the complicated mechanisms involved
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Extra resources for Molecular Pathology of Pituitary Adenomas (Elsevier Insights)
Prognosis is based on the mitotic index. Several biomarkers can be evaluated by appropriate immunodetection techniques: cyclins A, B, D, and E, proliferating cell nuclear antigen (PCNA) Ki-67, proliferating inhibitory proteins p16, p27, and p53, and DNA topoisomerase IIα. A marker for apoptosis and its inhibitors also may be important. According to Kontogeorgos and Kovacs , the MIB-1 LI is the most reliable marker. Cyclins control transitions between phases of the cell cycle by activating CDKs.
19. , et al. (2000) Effect of dopamine agonists on lactotroph adenomas of the human pituitary. Endocr. , 11: 341–52. Proliferation 35 20. L. and Ezzat, S. (2002) Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells. , 12: 412–19. 21. J. , Jr. (1997) p53 expression in pituitary adenomas and carcinomas: Correlation with invasiveness and tumor growth fractions. Neurosurgery, 38(4): 765–70. ; discussion 770–1.
26(4): S75–80. 23. W. V. (2003) Cyclooxygenase-2 expression in human pituitary tumors. Cancer, 97(11): 2814–21. 24. , et al. (2007) Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line. Am. J. , 170(1): 356–65. 5 Apoptosis Pituitary adenomas are known to vary from the standpoint of their intrinsic aggressiveness, which might imply that a different therapeutical approach could be useful.