By Eric Vivier, James Di Santo, Alessandro Moretta (eds.)
To have fun the fortieth anniversary of the invention of typical Killer (NK) cells, this quantity specializes in the new advances in our knowing of NK cellphone improvement and differentiation and their acquisition of sensible houses, in addition to the newest versions for NK-cell research in mice and purposes in scientific drugs. NK cells have travelled a circuitous direction from their preliminary description as ‘spontaneous killers’ (for a few easily an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of motion in immune security and an enormous mediator of immune reactivity in wellbeing and fitness and disorder. jointly, those reports offer a well timed and concise photo of the evolution of NK cells as crucial brokers in immunity and as powerful guns opposed to affliction. This ebook deals an beautiful and insightful source for scientists and clinicians.
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Additional resources for Natural Killer Cells
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J Exp Med 186:1597–1602 Held W, Kunz B, Lowin-Kropf B, van de Wetering M, Clevers H (1999) Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1. Immunity 11:433–442 Held W, Clevers H, Grosschedl R (2003) Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. Eur J Immunol 33:1393–1398 Hess Michelini R, Doedens AL, Goldrath AW, Hedrick SM (2013) Differentiation of CD8 memory T cells depends on Foxo1.
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