Download Organic Cation Transporters: Integration of Physiology, by Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter PDF

By Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter

This cutting edge textual content explores the mobile delivery of natural cations, from practical and structural houses to pharmacological implications and psychiatric advancements. The authoritative chapters introduce natural cation transporters after which continue to debate their mechanisms comparable to binding of substrates and inhibitors; their drug inclinations and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological structures. the ultimate chapters delve into using animal types for the learn of natural cation transporter functionality and their attainable use in environmental biking of pharmaceutical residues.

This complete quantity unites integrative transporter body structure with structural and molecular biology, genetics, pharmacology and pathophysiology, providing a holistic method of using this novel process in physiological contexts. it is going to end up beneficial analyzing for researchers and scholars in quite a few components of integrative, organ, telephone and molecular body structure in addition to pharmacologists and neurologists.

Show description

By Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter

This cutting edge textual content explores the mobile delivery of natural cations, from practical and structural houses to pharmacological implications and psychiatric advancements. The authoritative chapters introduce natural cation transporters after which continue to debate their mechanisms comparable to binding of substrates and inhibitors; their drug inclinations and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological structures. the ultimate chapters delve into using animal types for the learn of natural cation transporter functionality and their attainable use in environmental biking of pharmaceutical residues.

This complete quantity unites integrative transporter body structure with structural and molecular biology, genetics, pharmacology and pathophysiology, providing a holistic method of using this novel process in physiological contexts. it is going to end up beneficial analyzing for researchers and scholars in quite a few components of integrative, organ, telephone and molecular body structure in addition to pharmacologists and neurologists.

Show description

Read Online or Download Organic Cation Transporters: Integration of Physiology, Pathology, and Pharmacology PDF

Best organic books

A Vineyard Odyssey: The Organic Fight to Save Wine from the Ravages of Nature

A winery Odyssey is an interesting saga of wine—the trip from vine to bottle—that takes the reader on a travelogue of the various risks that lie alongside the way in which. John Kiger tracks the nefarious denizens of the winery international: the host of bugs, fungi, micro organism, and viruses, in addition to the feathered and bushy critters, that lurk in vineyards.

Glycoconjugates

Roswell Park melanoma Institute, Buffalo, ny. complete, present precis of glycoconjugate biochemistry for researchers and complicated scholars. 29 participants. DNLM: Glycoconjugates.

Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective

This e-book makes a speciality of the drug discovery and improvement purposes of transition steel catalyzed methods, which could successfully create preclinical and scientific drug applicants in addition to advertised drugs.  The authors pay specific realization to the demanding situations of transitioning academically-developed reactions into scalable business procedures.

Ecocatalysis : a new integrated approach to scientific ecology

Reconquest of biodiversity; remediation of degraded and anthropic parts, prevention of environmental health and wellbeing hazards; eco-innovation; eco-friendly . .. the present French targets are heavily relating to an interdisciplinary method of medical ecology, all of which perform the predicted commercial renewal.

Additional resources for Organic Cation Transporters: Integration of Physiology, Pathology, and Pharmacology

Sample text

2014;28(1):65–77. x. 25. Lozano E, Herraez E, Briz O, Robledo VS, Hernandez-Iglesias J, Gonzalez-Hernandez A, et al. Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology. Biomed Res Int. 2013;2013:692071. 1155/2013/692071. 26. Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH. Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol. 2003;23(21):7902–8.

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol. 2003;23(21):7902–8. 27. Nies AT, Hofmann U, Resch C, Schaeffeler E, Rius M, Schwab M. Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs). PLoS One. 2011;6(7):e22163. 0022163. 28. Jacobsson JA, Haitina T, Lindblom J, Fredriksson R. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family.

71. Karbach U, Kricke J, Meyer-Wentrup F, Gorboulev V, Volk C, Loffing-Cueni D, et al. Localization of organic cation transporters OCT1 and OCT2 in rat kidney. Am J Physiol Renal Physiol. 2000;279(4):F679–87. 72. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K. Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001;18(11):1528–34. 73. Slitt AL, Cherrington NJ, Hartley DP, Leazer TM, Klaassen CD. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels.

Download PDF sample

Rated 4.56 of 5 – based on 39 votes