By Alfred Hassner, Irishi Namboothiri
Organic Syntheses in keeping with Named Reactions is an imperative reference significant other for chemistry scholars and researchers. development on Hassner & Stumer's very popular 2e, this new paintings studies 750 reactions, with over a hundred new stereoselective and regioselective reactions. every one A-Z access offers a gently condensed precis of worthwhile details chemist must comprehend and make the most of those basic reactions of their paintings, together with short functional info. The publication is illustrated with actual man made examples from the literature and approximately 3,400 references to the first literature to assist extra interpreting. vast indexes (name, reagent, response) and a really priceless sensible workforce transformation index support the reader totally navigate this large selection of very important reactions. With its complete insurance, exceptional association and caliber of presentation, this long-awaited new version belongs at the shelf of each natural chemist.
* convenient reference consultant that explains 750 proven named procedures and strategies which are relied on and utilized by natural chemists to synthesise or rework molecules * presents key facts on each one transformation together with historical past, mechanism and uniquely to books during this region experimental info * vast and a number of indexes enable the reader to go looking for info as and the way they wish and to quickly plan transformations
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Additional info for Organic Syntheses Based on Name Reactions: a practical guide to 750 transformations (3rd Edition)
T. the mixture was diluted with EA (10 mL), filtered (Celite) and concentrated in vacuo. 19) afforded 4 (94%, mp 87–88 C). B 20 1 2 3 4 5 Baeyer A Muchowski JM Buchwald Sl Studer A Udea S Chem Ber Can J Chem J Am Chem Soc Org Lett Chem Commun 1878 1969 2003 2004 2010 11 47 125 6 46 582 657 12084 3477 2462 BAEYER–VILLIGER Aromatic Tritylation Acid catalyzed introduction of a triphenylmethyl group 2 into an aromatic ring 4, 5 (like a phenol); a Friedel–Crafts reaction. t. 5 g). 90 g) was added.
CHCl3, NaOH, acetone 2 R R3 O O O 6 5 4 Boc 3, 56%12 1 R3 H R N 4 R R2 R2 CH2Cl2, BnEt3NCl 1 CO2H 2. 58 g, 18 mmol). t. The precipitate was filtered, dissolved in water and extracted with diethyl ether (3 Â 20 mL). The aqueous layer was cooled, acidified with 2M HCl and extracted with EA (2 Â 20 mL). 47 g (56%) of 3 as a pale yellow solid on recrystallization from hexane/EA (4:1). 1 2 3 4 5 6 7 8 9 10 11 12 Bargellini G Korger G Reeve W Lai JT Corey EJ Rychnovsky SD Abraham DJ Fitzgerald RN Cvetovich RJ Venkateswaran RV Venkateswaran RV Butcher KJ Gazz Chim Ital Chem Ber Synthesis Synthesis J Am Chem Soc J Org Chem J Med Chem Synthesis J Org Chem Tet Lett Tetrahedron Tet Lett 1906 1963 1971 1984 1992 1998 2002 2004 2005 2005 2007 2009 36 96 – – 114 63 45 70 46 63 50 329 10 131 124 1906 6363 1184 1959 8560 8741 12026 2497 B 32 BARLUENGA Iodination Reagent Bis-(pyridine)iodonium tetrafluoroborate reagent 1 used in 1,2-iodofunctinalization of isolated or conjugated olefins, cyclization of alkynyl sulfides, oxidation of alcohols (5 Æ 6).
1 2 3 4 5 6 7 8 9 10 11 12 Atherton FR, Todd AR Wadsworth WS Zwierzak A Lukanow LK Hovalla D Garrigue B Liu LZ Zhao YF Mielniczak G Zhao YF Ju Y Donghi M J Chem Soc J Am Chem Soc Synthesis Synthesis Tet Lett Syn Comm Org Prep Proc Int J Chem Res S Syn Comm Synlett Synthesis Bioorg Med Chem Lett 1945 1962 1982 1985 1992 1995 1996 2003 2003 2005 2007 2009 64 33 25 28 33 19 660 1316 922 671 2817 871 490 262 3851 1927 407 1392 15 AUWERS Flavone Synthesis A Synthesis of benzopyran-4-ones 4, 8 (flavones) from o-hydroxychalcones 5 or from benzofuran-3-ones 1.