Download Organic Transistor Devices for In Vitro Electrophysiological by Andrea Spanu PDF

By Andrea Spanu

This thesis studies on a unique procedure for extracellular recordings of the task of excitable cells, which depends upon an natural, charge-modulated field-effect transistor (FET) referred to as OCMFET. The e-book indicates how, due to the intrinsic biocompatibility, lightness, and inexpensiveness of the cloth used, this new method is ready to triumph over a number of difficulties normal of of “classic” digital and bioelectronic. It offers a whole description of the process, including a finished document of the profitable experimental trials conducted on either cardiac and nerve cells, and a concise but entire review of bioelectronic interfaces and natural sensors for electrophysiological applications.

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By Andrea Spanu

This thesis studies on a unique procedure for extracellular recordings of the task of excitable cells, which depends upon an natural, charge-modulated field-effect transistor (FET) referred to as OCMFET. The e-book indicates how, due to the intrinsic biocompatibility, lightness, and inexpensiveness of the cloth used, this new method is ready to triumph over a number of difficulties normal of of “classic” digital and bioelectronic. It offers a whole description of the process, including a finished document of the profitable experimental trials conducted on either cardiac and nerve cells, and a concise but entire review of bioelectronic interfaces and natural sensors for electrophysiological applications.

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7. Despite the different, quite unusual, and rather complicated experimental approaches, the mechanism underling the transduction mechanism is still not clear. e. 1 Organic Field Effect Transistors 35 Fig. 7 Patch clamp validation experiments of the OCST device. a Intracellular voltage trace recorded in the patch-clamp experiment before and during pulsed OCST stimulation (upper inset). b Intracellular voltage trace recorded in the patch-clamp experiment implementing a continuous ramp stimulation protocol (upper inset).

19(16), 6767– 6773 (1999) 43. : Joining microelectronics and microionics: nerve cells and brain tissue on semiconductor chips. Solid-State Electron. 52(9), 1364–1373 (2008) 44. : Electrical interfacing of nerve cells and semiconductor chips. Chemphyschem: Eur. J. Chem. Phys. Phys. Chem. 3(3), 276–284 (2002) 45. : Neuron-silicon junction with voltage-gated ionic currents. Eur. J. Neurosci. 10(6), 1956–1962 (1998) 46. : Neuron adhesion on a silicon chip probed by an array of field-effect transistors.

11). More precisely, the transistor response resulted from the average change in the cleft potential caused by the simultaneous activity of the cells ensemble (see Fig. 12). Although this was a very interesting attempt, the device dimensions, which are several orders of magnitude greater than typical dimensions of electrodes for in vitro or in vivo applications (2 mm2 compared to 7 × 10−4 mm2 , which is the area of a standard planar microelectrode), and its working principle are not suitable for the detection of local field potentials (LFPs) nor action potentials (APs).

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