By M. J. Groves
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Extra resources for Parenteral Products. The Preparation and Quality Control of Products for Injection
The oldest and most fundamental of these is, of course, dextrose although its utilization depends upon insulin levels. The fact that it has a low renal threshold and requires a large quantity of liquid as a vehicle imposes restraints on its use as a source of calories in parenteral nutririon. Fructose is another hexavalent monosaccharide, like dextrose, but it is more rapidly metabolized without the intervention of insulin. This also applies to sorbitol which is an alcoholic hexahydrate sugar which can be used even in the presence of severe liver damage.
T. (1960). An examination of the decomposition of dextrose solution during sterilisation. Journal of Pharmacy and Pharmacology, 12, 19 IT. Wretlind, A. (1964), The pharmacological basis for the use of fat emulsions in intravenous nutrition, >1 CÍA Chirurgiealis Scandinavia, Suppl. 325, 31. Züversmit, D. , Salky, N. , TrumbuU, M. L. and McCandless, E. C. (1956). Preparation and use of anhydrous fat emulsions for intravenous feeding. Journal of Laboratory and Clinical Medicine, 48, 386. 47 Chapter 3 FUtratíon INTRODUCTION Filtration can be defined as the separation of undissolved particles or fibres from a liquid or gas by passage of the liquid or gas through a septum or porous medium which allows the fluid or gas to pass.
Some materials exist in more than one crystalline state although usually only one of the forms is stable under normal ambient conditions. However, changes of temperature during a milling process, contact with a solvent or even water is enough to induce polymorphic changes. Reversion to the stable form can be quite rapid or it can be very slow so that a meta-stable form may exist under ambient conditions. Since the solubilities of different polymorphs in water can be quite different, polymorphism influences the rate of physiological absorption in some cases.