Download Pediatric Neuropathology: A Text-Atlas by Dawna Armstrong, William Halliday, Cynthia Hawkings, Sachio PDF

By Dawna Armstrong, William Halliday, Cynthia Hawkings, Sachio Takashima

Neuropathology is the root for figuring out developmental neuroscience, pediatric neurology, and neurosurgery, yet formerly a accomplished quantity protecting all facets of pediatric neuropathology used to be no longer on hand. This atlas is hence a special, complete reference supplying the basics of developmental mind issues of the fearful approach which can impact fetuses, babies and little ones, in addition to the necessities of prognosis in developmental mind pathology and neuroimaging. With an emphasis at the attribute morphology and a concise precis of scientific gains, pathogenesis, and genetics, the generously illustrated atlas offers greater than a hundred issues, together with the typical ailments of the peripheral fearful method in addition to genetically decided metabolic and garage illnesses. This compilation is a precious source for pathologists, pediatric neurologists and neurosurgeons, geneticists, neonatologists, radiologists, and pediatricians.

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By Dawna Armstrong, William Halliday, Cynthia Hawkings, Sachio Takashima

Neuropathology is the root for figuring out developmental neuroscience, pediatric neurology, and neurosurgery, yet formerly a accomplished quantity protecting all facets of pediatric neuropathology used to be no longer on hand. This atlas is hence a special, complete reference supplying the basics of developmental mind issues of the fearful approach which can impact fetuses, babies and little ones, in addition to the necessities of prognosis in developmental mind pathology and neuroimaging. With an emphasis at the attribute morphology and a concise precis of scientific gains, pathogenesis, and genetics, the generously illustrated atlas offers greater than a hundred issues, together with the typical ailments of the peripheral fearful method in addition to genetically decided metabolic and garage illnesses. This compilation is a precious source for pathologists, pediatric neurologists and neurosurgeons, geneticists, neonatologists, radiologists, and pediatricians.

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Extra info for Pediatric Neuropathology: A Text-Atlas

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15 Walker-Warburg Syndrome Walker-Warburg syndrome was described as a cerebroocular disorder exhibiting type 2 lissencephaly, hydrocephalus, and eye abnormalities. The syndrome is also known as HARD+E (hydrocephalus, agryria, retinal dysplasia, encephalocele). The association with muscle disease was not made in early reports. Infants present with profound psychomotor retardation, hydrocephalus, and developmental defects; and they die during early infancy [2]. The brain exhibits a cobblestone (type 2) lissencephaly, polymicrogyria-pachygyria involving almost the whole cortical layer, overmigration of cortical neurons through the subpial membrane, diffuse polymicrogyria in the cerebellar hemispheres, aqueductal obstruction, hydro- cephalus, and brain stem dysplasia.

1. Chromosome 17-related a. Miller-Dieker syndrome, LIS1 [34,35] b. Isolated lissencephaly sequence 2. X-linked a. Lissencephaly, male: doublecortin [36] b. Subcortical band heterotopias, female: doublecortin [36] 3. Other loci a. Autosomal recessive lissencephaly with cerebellar hypoplasia, reelin [36] b. Familial bilateral periventricular nodular heterotopia, females: FLN1 (filamin) [36] c. X-linked lissencephaly with abnormal genitalia [XLAG, ARX (aristaless-related homeobox)] [37,38]) There is a correlation between the clinical abnormality and the pathology so a pathology classification was devised [39] and genetic differences have now been detected.

Malformations Fig. 13-7. Hemimegalencephaly. Left. Basal view of the brain. Right. CT findings. Left cerebral hemisphere is larger than the right one. Fig. 13-8. Hemimegalencephaly. Left. Cerebral hemispheres. Right. Cerebellar hemispheres. Left hemisphere is larger than the right one in both cerebrum and cerebellum. Hemimegalencephaly and Focal Cortical Dysplasia 41 Fig. 13-9. Hemimegalencephaly. NF immunohistochemistry shows that large neurons are scattered in the subcortical white matter. Fig.

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