By Erhard Gross, Johannes Meienhofer
Hardcover booklet provides cutting-edge (ca 1981) in security of sensible teams in peptide synthesis. quantity three.
Read Online or Download Protection of Functional Groups in Peptide Synthesis. The Peptides: Analysis, Synthesis, Biology PDF
Similar organic books
A winery Odyssey is an engaging saga of wine—the trip from vine to bottle—that takes the reader on a travelogue of the various risks that lie alongside the way in which. John Kiger tracks the nefarious denizens of the winery global: the host of bugs, fungi, micro organism, and viruses, in addition to the feathered and hairy critters, that lurk in vineyards.
Roswell Park melanoma Institute, Buffalo, long island. complete, present precis of glycoconjugate biochemistry for researchers and complex scholars. 29 participants. DNLM: Glycoconjugates.
This publication specializes in the drug discovery and improvement purposes of transition steel catalyzed procedures, that could successfully create preclinical and medical drug applicants in addition to advertised drugs. The authors pay specific recognition to the demanding situations of transitioning academically-developed reactions into scalable business tactics.
Reconquest of biodiversity; remediation of degraded and anthropic parts, prevention of environmental overall healthiness hazards; eco-innovation; eco-friendly . .. the present French targets are heavily regarding an interdisciplinary method of clinical ecology, all of which perform the predicted commercial renewal.
- Annual Reports in Medicinal Chemistry, Vol. 35
- Organic Reaction Mechanisms 1990
- Molecular Spectroscopy Volume 5
- Handbook of Heterocyclic Chemistry
Extra info for Protection of Functional Groups in Peptide Synthesis. The Peptides: Analysis, Synthesis, Biology
2-Halide-Substituted-Ethyloxycarbonyl Groups. This type of amine protection has been applied when smooth deprotection in neutral solution was desirable. The chlorocarbonates of these compounds are stable reagents for the acylation of amine groups. The deprotection of 2-bromoethyloxycarbonyl (Bee) amine compounds (27, see Table V) (Brugger, 1965; Büchi, 1965) by AgC10 4 in acqueous acetone is so mild that protecting groups that are sensitive to acids, bases, or hydrogénation are not affected. Therefore, the main application of these residues lies in the preparation of intermediates bearing labile protection.
With trifluoroacetic acid anhydride in trifluoroacetic acid Na-trifluoroacetyl derivatives are exclusively formed (Weygand and Geiger, 1956). Acetic acid anhydride in formic acid yields the α-formyl derivative (Hofmann et ai, 1960). Another route to α-protection proceeds via the ω-benzylidene compounds, which can be isolated without difficulty (Bezas and Zervas, 1961; Wünsch and Zwick, 1964). After protection of the α-amino group, the benzylidene residue is removed by treatment with acid. The liberated ωamino group is then derivatized with the second protecting group.
More advantageously, the course of the hydrogénation can be controlled by automated titration of the liberated amine group at about pH 4, for example, with HC1 or toluenesulfonic acid. The search for additional deblocking conditions led to the cleavage by HBr in acetic acid as a standard method (Ben Ishai and Berger, 1952). Sakakibara et al. (1967) introduced the liquid hydrogen fluoride cleavage, which by now is generally used for the removal of all acid-sensitive protecting groups. A related reagent is pyridinium polyhydrogen fluoride (Matsuura et αί, 1976).