By G.T. Szeifert, D. Kondziolka, M. Levivier, L.D. Lunsford
A result of large scientific adventure that has been accrued in radiosurgery, it kind of feels well timed to discover and approach out systematically pathological basics at the influence of targeted irradiation. the higher knowing of radiobiology will increase the results of radiosurgical strategies. well known specialists from around the world speak about the baselines of pathology and radiobiology, clinical actual rules, dose prescription guidance, present radiosurgical innovations, complex desktop expertise and up to date imaging tools in radiosurgery. during this specified quantity the main pioneering characteristic is the parallel dialogue of medical radiosurgical effects with basic pathological findings following high-dose centred irradiation. themes diversity from benign and malignant mind tumors, vascular malformations, useful problems, ocular and spinal radiosurgery, interstitial brachytherapy to experimental efforts. This ebook offers neurosurgeons, radiosurgeons, radiologists, pathologists, scientific physicists, neurologists, oncologists, ophthalmologists, otolaryngologists in addition to nuclear medication and scientific details know-how specialists an outstanding realizing of the most recent improvement of pathological basics and new tendencies in radiosurgery.
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Extra resources for Radiosurgery and Pathological Fundamentals
The father of pathological anatomy, Giovanni Battista Morgagni (1682–1771), had started his regular autopsy studies because he was not happy with the unexplainable physical signs and symptoms, and wanted to reveal the overlying pathophysiological process leading to disturbance of the human organism. Although anatomical lessons had been performed before Morgagni as well, the systematic comparison of clinical symptoms and signs with anatomic findings and logical correlation between the two graduated him as a dedicated master of clinical pathology .
Stereotact Funct Neurosurg 1996;66(suppl 1):4–16. Szeifert GT, Salmon I, Rorive S, Massager N, Devriendt D, Simon S, Brotchi J, Levivier M: Does gamma knife radiosurgery stimulate cellular immune response to metastatic brain tumors? A histopathological and immunohistochemical study. J Neurosurg 2005;102(suppl):180–184. Yamamoto M, Jimbo M, Kobayashi M, Toyoda C, Ide M, Tanaka N, Lindquist C, Steiner L: Longterm results of radiosurgery for arteriovenous malformation: neurodiagnostic imaging and histological studies of angiographically confirmed nidus obliteration.
Over time, cells can repair sublethal radiation-induced damage . 5 h in the central nervous system . An obvious effect of dose rate that pertains to radiosurgery systems is the decay in cobalt activity found with the Gamma Knife. Since the half-life of cobalt is approximately 5 years, a dose rate effect can be postulated. In our clinical experience however, we have not been able to define an effect of dose rate within our own patient series. Larson hypothesized that the concept of microfractionation might be important in reducing morbidity simply by delaying treatment times between radiosurgery isocenters at different stereotactic coordinates (within the same overall procedure) .