By H. Schonewille
Present pre-transfusion coverage calls for the sufferers' serum to be validated for the presence of abnormal purple blood mobile antibodies. In case of an alloantibody, crimson blood cells missing the corresponding antigen are transfused after an antiglobulin crossmatch. the purpose of the stories during this thesis is essentially to enquire even if this coverage may still switch to enhance transfusion defense. This thesis explores the danger on pink blood mobile alloimmunization after blood transfusion in oncohematologic sufferers and in sufferers who already shaped antibodies after a prior transfusion occasion. moreover, the dangers of present pretransfusion trying out in regards to antibodies to low prevalence antigens, timing of antibody checking out and antibody patience have been studied.
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Additional info for Red Blood Cell Alloimmunization after Blood Transfusion (LUP Dissertations)
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Oncol. 1999;21:224-230 Strauss RG, Johnson K, Cress G, Cordle DG. Alloimmunization in preterm infants after repeated transfusions of WBC-reduced RBCs from the same donor. Transfusion 2000;40:1463-1468 3 ALLOIMMUNIZATION TO RED BLOOD CELL ANTIGENS AFTER UNIVERSAL LEUCODEPLETION. A REGIONAL MULTICENTRE RETROSPECTIVE STUDY ` Henk Schonewille, Anneke Brand. Alloimmunization to red blood cell antigens after universal leucodepletion. A regional multicenter study. Brit. J. Haematol. 2005;129:151-156 Chapter 3 SUMMARY Leucodepletion has shown to reduce human leucocyte antigen immunization, but studies on the effect of leucodepletion on red cell alloimmunization reported discordant results.