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By Somani S.M.

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By Somani S.M.

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The reversal by pyridostigmine of neuromuscular block produced by soman, J. Pharm. Pharmacol. 31, 290, 1979. 84. P. , HI-6 as an antidote to soman poisoning in rhesus monkey respiratory muscles in-vitro, J. Pharm. , 35, 157, 1983. 85. , Therapy of organophosphate poisoning: The marmoset as a model for man, Br. J. , 78, 579, 1983. 86. M. , The role of cholinesterase in the myoneural junction, Br. J. , 8, 334, 1953. 87. , Cholinesterase inhibition and the effect of anticholinesterases on indirectly evoked single and tetanic muscle contractions in the phrenic nerve-diaphragm preparation from the rat, Arch.

The one effect that seems to occur at a sufficiently low concentration of organophosphorus anticholinesterase to be considered a low-dose phenomenon is the slow allosteric modulation of muscarinic receptors regulating presynaptic release of other neurotransmitters. The observation that this allosteric modulation requires several hours to develop suggests that this mechanism would most likely be applicable to a subacute or subchronic exposure rather than one seen after a brief, acute dose. V. SUMMARY AND CONCLUSIONS We believe that studies to determine the potential long-term psychologic/neurologic sequelae following repeated low-level exposures to OP are confounded by factors such as low response rates, possible selection and follow-up biases (which is certainly the case for nerve CW agent), compensatory psychological response, possible co-exposures and the like.

8, 33, 1997. 29. , A case of VX poisoning and the difference from sarin, Lancet, 346, 698, 1995. 30. , Persistent effects of sarin and dieldrin upon the primate electroencephalogram, Toxicol. Appl. , 35, 365, 1976. 31. , and Wilbur, E. , Effects of a single 1/2 LD50 of GB upon delayed response and conditional avoidance tests, Edgewood Arsenal Technical Report 4489, 1971. 32. , Long-term effects of an organophosphate upon the human encephalogram, Toxicol. Appl. , 47, 161, 1979. 33. R. , EEG, psychological and neurological alterations in humans with organophosphorus exposure, Ann.

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