By Kanniah Rajasekaran, Jeffrey W. Cary, Jesse M. Jaynes, Emilio Montesinos
content material: Immunomodulatory cationic peptide therapeutics : a brand new paradigm in an infection and immunity --
Structure/function hyperlink among cytokine domain names and ordinary and designed lytic peptides : clinical promise --
the opportunity of frog pores and skin antimicrobial peptides for improvement into therapeutically invaluable anti-infective brokers --
hindrances and options to using cationic antimicrobial peptides within the remedy of melanoma --
Lytic peptides as anti-cancer therapeutics : classes discovered from a unique layout method --
innovations for designing peptide immunogens to elicit : helical conformation-specific antibodies reactive with local proteins --
Defensins in viral an infection --
"GENOPEP," a topical cream within the therapy of burn wounds --
constructing influenza antigen microarrays for seroprofiling --
pH-directed self-assembling helical peptide conformation --
Controlling symbiotic microbes with antimicrobial peptides --
Antimicrobial peptides for plant sickness keep an eye on : from discovery to program --
Antimicrobial peptides as a promising substitute for plant affliction safeguard --
recommendations for controlling plant ailments and mycotoxin illness utilizing antimicrobial man made peptides --
Antifungal plant defensins : structure-activity relationships, modes of motion, and biotech purposes --
Antifungal peptides : exploiting non-lytic mechanisms and mobilephone penetration houses --
Thionin antifungal peptide synthesis in transgenic barley --
Expression of designed anti-microbial peptides in theobroma cacao L. bushes reduces leaf necrosis as a result of phytophthora spp --
Antimicrobial peptides for fireplace blight regulate --
Thionins : nature's guns of mass security --
Transgenic expression of antimicrobial peptides in vegetation : ideas for more advantageous illness resistance, greater productiveness, and construction of therapeutics.
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Extra info for Small Wonders: Peptides for Disease Control
H. Increasing bacterial disease resistance in plants utilyzing antibacterial genes from insects. BioEssays 1987, 6, 263–70. 59. Jaynes, J. ; Hammerschlag, F. ; Zimmerman, L. ; Owens, L. D. Use of genes encoding novel lytic peptides and proteins that enhance microbial disease resitance in plants. Acta Horticulturae, Second International Symposium on In Vitro Culture and Horticultural Breeding 1993, 336, 33–39. 60. Cary, J. ; Jaynes, J. ; Cleveland, T. E. Transgenic expression of a gene encoding a synthetic antimicrobial peptide results in inhibition of fungal growth in vitro and in planta.
Bellail, A. ; Van Meir, E. G. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro-Oncology 2005, 7, 122–33. 19. Neville, L. ; Bagasra, O The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily. Cytokine Growth Factor Rev. 1998, 8, 207–19. 20. Angiolillo, A. ; Taub, D. ; Farber, J. ; Kleinman, H. ; Reaman, G. ; Tosato, G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.
The effect of a particular cytokine on a given cell depends on several factors: (I) the presence/abundance of the complementary receptor(s) on the cell surface, (II) its extracellular abundance and (III) the downstream signals activated by receptor binding; these last two factors are variable and depend upon type (5, 6), and the particular response of the responding cell. Chemokines are a subset group of small cytokines and are distinguished by their ability to induce directed chemotaxis in responsive cells in close proximity (7).