By Robert M. Nerem, Jeanne Loring, Todd C. McDevitt, Sean P. Palecek, David V. Schaffer, Peter W. Zandstra
This e-book describes an international evaluation of stem telephone engineering examine, accomplished via website visits by way of a panel of specialists to top institutes, by means of devoted workshops. The evaluate made transparent that engineers and the engineering process with its quantitative, system-based pondering can give a contribution a lot to the growth of stem phone examine and improvement. The elevated desire for advanced computational versions and new, leading edge applied sciences, resembling high-throughput screening recommendations, organ-on-a-chip versions and in vitro tumor versions require an expanding involvement of engineers and actual scientists. also, this booklet will convey that even though the united states remains to be in a management place in stem mobilephone engineering, Asian nations similar to Japan, China and Korea, in addition to ecu nations just like the united kingdom, Germany, Sweden and the Netherlands are swiftly increasing their investments within the box. Strategic partnerships among nations may lead to significant advances of the sector and scalable growth and differentiation of stem cells. This examine was once funded via the nationwide technology beginning (NSF), the nationwide Institutes of wellbeing and fitness (NIH) and the nationwide Institute of criteria and know-how (NIST).
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Extra resources for Stem Cell Engineering: A WTEC Global Assessment
Government to modify its own programs. S. research programs. To obtain the intended benefits, this study focused on a range of issues in which the R&D occurring abroad will best inform our own Government programs and the research community of the challenges, barriers, and opportunities in SCE. The study panel developed and refined the scope of the study, with the guidance of the sponsors. M. Nerem 4 • Long range research, educational, and infrastructure issues that need addressed to promote better progress in the field • Current government R&D funding levels overseas compared to the United States, to the extent data are available Prior Work at WTEC With core funding and management from the NSF Directorate for Engineering, WTEC has conducted over 60 international R&D assessments.
Although one might argue that the United States today has a leadership role, to capitalize on this and to build on the current existing momentum, and most importantly to accelerate the translation of bench-top research into various applications including clinical therapies and into commercialization, will require the United States taking bold steps. The panel thus offers the following conclusions. • The United States has a unique opportunity to maintain a leadership position in the stem cell field through the continued support of R&D that will provide a foundation for the generation of new markets and that will lead to economic growth.
Another issue is the multitude of parameters that are capable of affecting cell growth and phenotype. For process optimization there is a large experimental space that must be explored, and current high-throughput formats and screening platforms are inherently incapable of simulating bioprocess parameters. Finally, stem cell manufacturing facilities need to be developed as closed culture systems with a miniaturized “foot print” and composed of modular elements. They need to incorporate real-time monitoring, feedback-based control, and learning-based algorithms.