By Daniel Lednicer
The vintage reference at the synthesis of medicinal brokers --now thoroughly updatedThe 7th quantity within the definitive sequence that offers a brief but thorough review of the factitious routes used to entry particular classesof healing brokers, this quantity covers nearly 220 new non-proprietary drug entities brought because the e-book of quantity 6.Many of those compounds signify novel structural forms firstidentified by means of subtle new cell-based assays. in particular, an important variety of new antineoplastic and antiviral brokers are covered.As within the prior volumes, fabrics are geared up by way of chemical category and syntheses originate with to be had beginning fabrics. geared up to make the data obtainable, this source covers ailment kingdom, purpose for approach to drug treatment, and the organic actions of every compound and coaching. The natural Chemistry of Drug Synthesis, quantity 7 is a hands-on reference for medicinal and natural chemists, and a very good source for graduate and complex undergraduate scholars in natural and medicinal chemistry.
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Extra info for The Organic Chemistry of Drug Synthesis (Organic Chemistry Series of Drug Synthesis) (Volume 7)
Med. Chem. 41, 3387 (1998). 7. For a scheme for this intermediate see D. Lednicer,“The Organic Chemistry of Drug Synthesis”, Vol. , NY 1999, pp. 12,13. 8. J. , Org. Process Res. Dev. 4, 264 (2000). 9. S. , J. Med. Chem. 42, 1213 (1999). 10. A. , J. Med. Chem. 47, 4774 (2004). 11. M. H. Lyttle, A. S. Patent 5,556,942 (1996). 12. A. D. A. S. O. H. Lyttle, J. Med. Chem. 39, 1736 (1996). 13. A. McIntyre, J. Castaner, Drugs Future 29, 992 (2004). 14. A. Sartorelli, K. S. Patent 4,684,747 (1987). 15.
There is thus obtained the acetamido azide (33). Repeat of the sequence, mesylate formation followed by catalytic hydrogenation leads to formation of a new aziridine (33), in which the ring has moved over by one carbon atom. Reaction of this last intermediate with 3-pentanol in the presence of base leads to opening the aziridine ring to give the corresponding ether. The azide in this last intermediate is again reduced with hydrogen. 6 – 8 The importance of this drug to meet a potential worldwide pandemic has attracted the attention of academic chemists.
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