By M. Zamir
This ebook is dedicated to the dynamics and physics of coronary blood movement. whereas it acknowledges the variety of scientific and pathophysiological matters concerned, the publication makes a speciality of dynamics and physics, coming near near the topic from a biomedical engineering perspective. With this process, the ebook will supplement different books at the topic that experience to date centred principally on medical and pathophysiological matters. the writer, initially proficient in fluid dynamics, has been instructing and dealing at the dynamics of blood move regularly and coronary blood move specifically for the prior thirty years and has produced a booklet that would attract physicians, physicists and engineers.
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Extra resources for The Physics of Coronary Blood Flow (Biological and Medical Physics, Biomedical Engineering)
It also depends on the form of the driving pressure, in particular whether the pressure is steady or pulsatile. The relation between pressure and ﬂow in a vascular tree structure consisting of a large number of tube segments depends not only on all such factors in each tube segment but also on events at the junctions between tube segments and on how the properties of individual segments are distributed within the tree structure. The overwhelming complexity of this problem gives rise to the “lumped model” concept.
The ﬁgure illustrates the range of variability in the way in which the two arteries share the responsibility of cardiac blood supply. At one extreme (a), known as “left-dominant”, the left coronary artery gives rise to the posterior descending artery and therefore blood supply to the left ventricle depends on vasculature arising entirely from the left coronary artery. In a “balanced” case (b), the right coronary artery gives rise to the posterior descending artery and thereby contribute to blood supply to the interventricular wall, which is an important part of the left ventricle.
The latter are part of the ﬂuid dynamic design of the cerebral circulation, that is, part of the normal anatomy of the cerebral vasculature. Collateral vasculature in the human heart is not part of the normal anatomy of the coronary vasculature. The overwhelming majority of heart failures caused by insuﬃcient myocardial blood supply [185, 173, 27, 15, 69, 16, 74, 95] point clearly to a failure of this mechanism in these cases. The diﬀerence between the time scale of development and growth of collateral vessels and the time scale of vascular obstruction, whether by a slow disease process or sudden occlusion, is clearly an important factor.