By Clemens Van Blitterswijk, Jan De Boer
Tissue Engineering isa accomplished creation to the engineering and organic elements of this serious topic. With contributions from the world over well known authors, it offers a vast point of view on tissue engineering for college kids coming to the topic for the 1st time. as well as the most important issues lined within the prior variation, this replace additionally contains new fabric at the regulatory specialists, advertisement issues in addition to new chapters on microfabrication, materiomics and cell/biomaterial interface.
- Effectively reports significant foundational subject matters in tissue engineering in a transparent and available fashion
- Includes cutting-edge experiments provided in break-out containers, bankruptcy pursuits, bankruptcy summaries, and a number of selection inquiries to relief learning
- New variation includes fabric on regulatory specialists and advertisement concerns in tissue engineering
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Additional resources for Tissue Engineering, Second Edition
MSCs can differentiate into cells that form bone, cartilage, and fat. n Oligopotent stem cells can differentiate into two or more lineages, for example, neural stem cells that can form a subset of neurons in the brain. n Unipotency is the ability to form cells of a single lineage, for example, spermatogonial stem cells. n The term omnipotence is not used for stem cells, but is used in religions as one of the God’s characteristics. n Differentiation is the process whereby stem cells transform into more specialized cell types and can perform new functions through the expression of new genes, mRNA, and proteins.
Proc. Natl. Acad. Sci. A. 110 (12), 4563–4568. , 2014. Tissue-engineered autologous vaginal organs in patients: a pilot cohort study. Lancet. 384 (9940), 329–336. , 1981. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc. Natl. Acad. Sci. A. 78 (12), 7599–7603. , 1983. Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix. Proc. Natl. Acad. Sci. A. 80 (21), 6591–6595. , 1961. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.
Ideally, and by definition, stem cells can grow forever. In practice, it is difficult to keep stem cells growing indefinitely, yet enough cells can be produced for a particular purpose and the remainder may be cryopreserved (frozen) for later use, or discarded. Early studies on aging of cells in culture using human fibroblasts found that after about 50–60 divisions the cells slowed and stopped growing (Hayflick, 1965; reviewed in Hayflick, 1998). Prior to this work it was assumed that cells in culture could divide an infinite number of times if proper conditions could be found.